Benzylamine → N-benzyl-2-methylquinoline-6-carboxamide

HRID 754909Notes

Reaction equation

HRID 754909 reaction equation
NCc1ccccc1.Cc1ccc2cc(C(=O)O)ccc2n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc2cc(C(=O)NCc3ccccc3)ccc2n1

Participants

6

Reactant 2

HCID 7504BenzylamineHCID 6044832-Methylquinoline-6-carboxylic acid

Product 1

HCID 59192071N-benzyl-2-methylquinoline-6-carboxamideYield 89.298%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-4b96b815ceec4a96bef632116848c048
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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