反应详情

To a solution of ethyl 2-acetamido-3-oxobutanoate (compound 10, 2.0 g, 10.6 mmol), aniline (compound 11b, 2.0 g, 21.3 mmol) in butyronitrile (15 mL) was added acetic acid (1.2 mL, 21.3 mmol) at room temperature. The reaction mixture was irradiated in a microwave reactor (Biotage Initiator™) for 40 minutes at 160° C. The mixture was concentrated under reduced pressure. The crude product was purified by preparative HPLC (purification system, Gilson) to provide the title compound (340 mg, 14%) as a brown oil.

1. customThe reaction mixture was irradiated in a microwave reactor (Biotage Initiator™) for 40 minutes at 160° C
2. concentrationThe mixture was concentrated under reduced pressure
3. customThe crude product was purified by preparative HPLC (purification system, Gilson)