反应详情

温度

150 °C

Ammonium sulfate (100 mg) was added to a solution of (E)-ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate (compound 18, 1.5 g, 5.9 mmol) and hexamethyldisilazane (15 mL) and refluxed overnight at 150° C. The reaction mixture was evaporated and extracted with EA and water. The organic layer was evaporated and the residue was purified with 20% methanol in CH2Cl2 to produce as a light brown solid (1.0 g, 71.4% yield).

1. customThe reaction mixture was evaporated
2. extractionextracted with EA and water
3. customThe organic layer was evaporated
4. customthe residue was purified with 20% methanol in CH2Cl2