1,4-Dioxane hydrochloride → HCID 178436377, compound

HRID 75505Notes

Reaction equation

HRID 75505 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]2[C:19]([CH2:20][CH3:21])=[CH:18][C:17]([CH2:22][CH3:23])=[N:16]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:25].O1CCOCC1>CO>[ClH:25].[CH2:22]([C:17]1[CH:18]=[C:19]([CH2:20][CH3:21])[N:15]([CH2:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[N:16]=1)[CH3:23]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178436379HCID 178436379, compound

Product 1

HCID 178436377HCID 178436377, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Trans-[4-(3,5-Diethyl-pyrazol-1-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester (80 mg, 0.24 mmol) was dissolved in MeOH (1 ml). 4M HCl/dioxan (1 ml) was added and the RM was stirred at RT for 2 hours. The solvent was removed in vacuo to afford the title product which was used without further purification; LC-MS Rt 1.59 mins [M+H]+ 236.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-ee3ce2ad3a124c4b968b9d7a7536f624
Source dataset
uspto-grants-2014_09
Patent number
US08835444B2

Reaction notes

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