Hydrazine hydrate (1:1) → HCID 178422720, compound

HRID 75511Notes

Reaction equation

HRID 75511 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=O)[CH2:8][C:9](=O)[CH3:10])[CH:2]=1.O.[NH2:14][NH2:15]>CO>[CH3:10][C:9]1[CH:8]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[NH:14][N:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 3001601-(Pyridin-3-yl)butane-1,3-dione

Product 1

HCID 178422720HCID 178422720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Pyridin-3-yl-butane-1,3-dione (step 1) (500 mg, 3.06 mmol) was dissolved in MeOH (20 ml). Hydrazine monohydrate (230 mg, 223 μl, 4.60 mmol) was added and the resulting mixture was stirred at RT for 1 hour. After cooling to RT, the solvent was removed in vacuo. The crude residue was dissolved in DCM, dried over (MgSO4) filtered and concentrated in vacuo to afford the title compound which was used without further purification.

Workup

  1. temperatureAfter cooling to RT
  2. customthe solvent was removed in vacuo
  3. dissolutionThe crude residue was dissolved in DCM
  4. dry with materialdried over (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8ec2aed3230440bc91c59ac10514a757
Source dataset
uspto-grants-2014_09
Patent number
US08835444B2

Reaction notes

Loading…