反应详情

温度

80 °C

A mixture of 3,3-difluoroazetidine-1-carbonitrile (135 mg, 1.14 mmol) and benzotriazole (136 mg, 1.14 mmol) in 1,2-dichloroethane (0.2 mL) was heated to 80° C. under nitrogen for 30 min. A needle was inserted to facilitate evaporation of the solvent and the mixture was heated at 80° C. for 45 min. The resulting solids were washed with ether (2×3 mL) and dried under reduced pressure to give the title compound as an off-white solid (160 mg, 51%).

1. customevaporation of the solvent
2. temperaturethe mixture was heated at 80° C. for 45 min
3. washThe resulting solids were washed with ether (2×3 mL)
4. customdried under reduced pressure