反应详情

A mixture of 3-bromobenzyl bromide (3.43 g, 13.73 mmol), 4,4-difluoro-piperidine hydrochloride (2.20 g, 13.97 mmol), and potassium carbonate (4.82 g, 34.86 mmol) in acetonitrile (50 mL) was stirred at RT for 16 h. The mixture was filtered and evaporated, and the residue partitioned between water (30 mL) and EtOAc (3×30 mL). The combined organic extracts were washed with water (2×50 mL) and dried (Na2SO4). The solvent was evaporated to give the title compound as a colourless oil (3.96 g, 99%). LCMS (Method 1): Rt 1.89 min, m/z 290/292 [MH+].

1. filtrationThe mixture was filtered
2. customevaporated
3. customthe residue partitioned between water (30 mL) and EtOAc (3×30 mL)
4. washThe combined organic extracts were washed with water (2×50 mL)
5. dry with materialdried (Na2SO4)
6. customThe solvent was evaporated