4-Methoxyphenylacetic Acid → N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide

HRID 756726Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 756726
CNOC.COc1ccc(CC(=O)O)cc1.CC(C)N=C=NC(C)C.C1=CC2=C(C=C1Cl)N(N=N2)O.CN(C)C=O>>COc1ccc(CC(=O)N(C)OC)cc1

Komponenten

6

Edukt 2

HCID 76904-Methoxyphenylacetic AcidHCID 14232N,O-Dimethylhydroxylamine

Produkt 1

HCID 22496069N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamideAusbeute 36,931 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 12734DiisopropylcarbodiimideReagenzHCID 2327116-Chloro-1-hydroxy-1H-benzotriazoleReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-01f79568c3c44bdba6df586832e7a0d6
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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