Phosphorus oxychloride → HCID 135752592, compound

HRID 7571Notes

Reaction equation

HRID 7571 reaction equation
[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]([CH:13]([NH:16][C:17]([CH:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=O)[CH2:14][CH3:15])=[N:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]3=[C:13]([CH2:14][CH3:15])[N:16]=[C:17]([CH:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:8]3[N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 135752635HCID 135752635, compound

Product 1

HCID 135752592HCID 135752592, compound

Procedure

In analogy to the procedure for Example 1, 290 mg (0.90 mmol) crude N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide, 140 mg (0.90 mmol) phosphoric trichloride are stirred at reflux for 3 hours, proportionate amounts of the solvents are used.

Workup

  1. temperatureat reflux for 3 hours

Sources & evidence

ORD record
ord-b416efe0b1cf4f3b91ebf5f5d14dabb6
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Reaction notes

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