Methylamine → 7-Methoxyquinazoline-4,6-diamine

HRID 75710Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH2:13])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[N+:14]([O-])=O.CN>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH2:13])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[NH2:14]

Participants

Reactant 2

HCID 6329Methylamine

HCID 666086197-Methoxy-6-nitroquinazolin-4-amine

Product 1

HCID 666095857-Methoxyquinazoline-4,6-diamineYield 92%

Procedure

The procedure of Example 23 was repeated except for using 7-methoxy-6-nitroquinazolin-4-ylamine instead of 7-methoxy-6-nitroquinazolin-4-yl)methylamine in <Step 7> to obtain the title compound (158 mg, 92%).

Sources & evidence

ORD record: ord-d31d7f768c4942b0a07bc71108debe6e
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08835458B2

Reaction notes

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