反应详情

A flask was charged with 1-amino-4-fluoro-4-(hydroxymethyl)cyclohexanecarbonitrile, Intermediate 32, (12.2 g, 70.8 mmol), CH2Cl2 (200 mL), water (80 mL) and benzyl chlorocarbonate (12.14 mL, 85 mmol) and the mixture stirred under nitrogen overnight. The CH2Cl2 portion of the reaction mixture was separated, washed with water then brine, dried (MgSO4) and concentrated to give a yellow oil. The oil was purified by column chromatography on silica gel, eluted with hexane/ethyl acetate (0 to 100%). The appropriate fractions were combined and the solvent evaporated to provide the title compound (13.1 g, 42.8 mmol, 60.4% yield)] as a colorless oil that crystallized upon standing.

1. customThe CH2Cl2 portion of the reaction mixture was separated
2. washwashed with water
3. dry with materialbrine, dried (MgSO4)
4. concentrationconcentrated
5. customto give a yellow oil
6. customThe oil was purified by column chromatography on silica gel
7. washeluted with hexane/ethyl acetate (0 to 100%)
8. customthe solvent evaporated