Phosphorus oxychloride → HCID 135752572, compound

HRID 7579Notes

Reaction equation

HRID 7579 reaction equation
[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]([CH:13]([NH:16][C:17]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]3[CH3:25])=O)[CH2:14][CH3:15])=[N:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]3=[C:13]([CH2:14][CH3:15])[N:16]=[C:17]([CH:19]4[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]4[CH3:25])[N:8]3[N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 135752633N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2-methylcyclohexanecarboxamide

Product 1

HCID 135752572HCID 135752572, compound

Procedure

In analogy to the procedure for Example 1, 200 mg (0.58 mmol) crude N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2-methylcyclohexanecarboxamide, 165 mg (1.1 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The isomers are purified by chromatography (preparative HPLC).

Workup

  1. temperatureat reflux for 4 hours
  2. customThe isomers are purified by chromatography (preparative HPLC)

Sources & evidence

ORD record
ord-ef45c28416254026af4c7d872c8778db
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Reaction notes

Loading…