反应详情

Ethyl 3-(4-amino-3-methylphenyl)isoxazole-5-carboxylate (1.0 equiv.), 2,4-difluoro phenyl isocyanate (1.2 equiv.) and tetrahydrofuran in a round-bottom flask was stirred at room temperature for 48 hours. The solid precipitate was filtered and washed with a minimum quantity of THF and dried in vacuo to afford the title compound as a white solid (75%); 1H NMR (300 MHz, DMSO-d6) δ: 1.29-1.34 (t, J=7.0 Hz, 3H), 2.29 (s, 3H), 4.32-4.39 (q, 2H), 7.00-7.05 (m, 1H), 7.26-7.33 (m, 1H), 7.72-7.75 (d, J=8.4 Hz, 1H), 7.80 (s, 2H), 8.09-8.16 (m, 2H), 8.45 (s, 1H), 9.09 (s, 1H); IR (KBr) 3297, 3134, 2991, 1727, 1654, 1590, 1558, 1500, 1460, 1424, 1287, 1250, 1139, 1029, 841 cm1.

1. filtrationThe solid precipitate was filtered
2. washwashed with a minimum quantity of THF
3. customdried in vacuo