Hydrochloric Acid → HCID 67352663, compound

Participants

Reaction Steps

To Methyl 2-(3-(4-(benzyloxy)phenyl)isoxazole-5-carboxamido)-3-methylbutanoate (150 mg) in THF (3 ml), 1 M aqueous solution of Lithium hydroxide monohydrate (0.735 ml) was added and reaction mixture was stirred at RT for 6 hours. The reaction mixture was acidified with dilute HCl and extracted with EtOAc. Organic layer was collected and dried over Na2SO4 and concentrated to obtain off white solid, which was crystallized from EtOAc to obtain the title compound as white solid. Yield: 80 mg (55%); MS (ES+): m/z 395 (M+1); 1HNMR (DMSO-d6; 300 MHz): δ 12.91 (bs, 1H), 8.94 (d, 1H), 7.87 (d, 2H), 7.69 (s, 1H), 7.32-7.49 (m, 5H), 7.19 (d, 2H), 5.19 (s, 2H), 4.28 (m, 1H), 2.22 (m, 1H), 0.96 (d, 6H).

Provenance & Evidence