反应详情

To Methyl 2-(3-(4-(benzyloxy)phenyl)isoxazole-5-carboxamido)-3-methylbutanoate (150 mg) in THF (3 ml), 1 M aqueous solution of Lithium hydroxide monohydrate (0.735 ml) was added and reaction mixture was stirred at RT for 6 hours. The reaction mixture was acidified with dilute HCl and extracted with EtOAc. Organic layer was collected and dried over Na2SO4 and concentrated to obtain off white solid, which was crystallized from EtOAc to obtain the title compound as white solid. Yield: 80 mg (55%); MS (ES+): m/z 395 (M+1); 1HNMR (DMSO-d6; 300 MHz): δ 12.91 (bs, 1H), 8.94 (d, 1H), 7.87 (d, 2H), 7.69 (s, 1H), 7.32-7.49 (m, 5H), 7.19 (d, 2H), 5.19 (s, 2H), 4.28 (m, 1H), 2.22 (m, 1H), 0.96 (d, 6H).

1. customreaction mixture
2. extractionextracted with EtOAc
3. customOrganic layer was collected
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customto obtain off white solid, which
7. customwas crystallized from EtOAc