Phosphorus oxychloride → HCID 135752596, compound

HRID 7585Notes

Reaction equation

HRID 7585 reaction equation
[CH:1]1([CH2:7][C:8]([NH:10][CH:11]([C:14]2[C:15](=[O:25])[NH:16][C:17]([CH:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[N:18][N:19]=2)[CH2:12][CH3:13])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[CH:1]1([CH2:7][C:8]2[N:19]3[C:14]([C:15](=[O:25])[NH:16][C:17]([CH:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)=[N:18]3)=[C:11]([CH2:12][CH3:13])[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1357525262-Cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide

Product 1

HCID 135752596HCID 135752596, compound

Procedure

In analogy to the procedure for Example 1, 200 mg (0.52 mmol) crude 2-cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide, 165 mg (1.1 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The product is purified by chromatography (preparative HPLC).

Workup

  1. temperatureat reflux for 4 hours
  2. customThe product is purified by chromatography (preparative HPLC)

Sources & evidence

ORD record
ord-5e11825c5d714cc6bbd7a0edf51373e8
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Reaction notes

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