Phosphorus oxychloride → HCID 135752648, compound

HRID 7587Notes

Reaction equation

HRID 7587 reaction equation
[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]([CH:13]([NH:16][C:17](=O)[C:18]([CH3:22])([CH3:21])[CH2:19][CH3:20])[CH2:14][CH3:15])=[N:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[CH:1]1([C:6]2[NH:11][C:10](=[O:12])[C:9]3=[C:13]([CH2:14][CH3:15])[N:16]=[C:17]([C:18]([CH2:19][CH3:20])([CH3:22])[CH3:21])[N:8]3[N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 135752605N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2,2-dimethylbutanamide

Product 1

HCID 135752648HCID 135752648, compound

Procedure

In analogy to the procedure for Example 1, 211 mg (0.66 mmol) crude N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-2,2-dimethylbutanamide, 165 mg (1.1 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The product is purified by chromatography (preparative HPLC).

Workup

  1. temperatureat reflux for 4 hours
  2. customThe product is purified by chromatography (preparative HPLC)

Sources & evidence

ORD record
ord-a83afc9421604769af37c08c2b3038bc
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Reaction notes

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