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HRID7588

反应详情

EQUATION

反应方程式

HRID 7588 的结构方程式

REACTANTS

反应物

2
结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：CCC(NC(=O)C1CCN(C(=O)OCc2ccccc2)CC1)c1nnc(C2CCCC2)[nH]c1=O
HCID135752573

未命名化合物

PRODUCTS

生成物

1
结构：CCc1nc(C2CCN(C(=O)OCc3ccccc3)CC2)n2nc(C3CCCC3)[nH]c(=O)c12
HCID135752579

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure for Example 1, 500 mg (1.07 mmol) crude benzyl 4-({[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]amino}carbonyl)-1-piperidinecarboxylate, 248 mg (1.7 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The product is purified by chromatography (preparative HPLC).

WORKUP

后处理

  1. temperatureat reflux for 4 hours
  2. customThe product is purified by chromatography (preparative HPLC)