Benzoyl chloride → 7-(1-Benzoyl-4-piperidinyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

HRID 7590Notes

Reaction equation

HRID 7590 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:6]2[C:11]=1[C:10](=[O:12])[NH:9][C:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[N:7]2)[CH3:2].[C:25](Cl)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:25]([N:22]1[CH2:23][CH2:24][CH:19]([C:5]2[N:6]3[C:11]([C:10](=[O:12])[NH:9][C:8]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[N:7]3)=[C:3]([CH2:1][CH3:2])[N:4]=2)[CH2:20][CH2:21]1)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 1357526105-ethyl-2-phenyl-7-(4-piperidinyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

Product 1

HCID 1357526737-(1-Benzoyl-4-piperidinyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Procedure

In analogy to the procedure for Example 103 Step (b), 30 mg (0.09 mmol) 5-ethyl-2-phenyl-7-(4-piperidinyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one, 14 mg (0.10 mmol) benzoyl chloride are stirred at room temperature overnight, proportionate amounts of the solvents are used.

Sources & evidence

ORD record
ord-c29c2191c2d443639bf07ca2ce43a00d
Source dataset
uspto-grants-2006_08
Patent number
US07087605B2

Reaction notes

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