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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76041Generated: October 29, 2026

Hydrochloric Acid → HCID 66615856, compound

https://huagongshe.com/reaction/76041

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant4-{4-[2-(3-Chlorophenylamino)-oxazol-5-yl]-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl esterHCID 66615830—
SolventMethanolHCID 887—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 66615856HCID 66615856—

Reaction Steps

To a solution of 4-{4-[2-(3-chlorophenylamino)-oxazol-5-yl]-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (2.5 g, 5.5 mmol) in MeOH (1 mL) is added 4M HCl in dioxane (3 mL) and the mixture is stirred at RT for 2 h. It is concentrated and used in the next step as the bis HCl salt: (M+H)+352.1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08835451B2
Source datasetuspto-grants-2014_09
ORD IDord-3e55c79cf2f748c7a39ab4b0f54f792a
Source noteuspto-grants-2014_09