Hydrochloric Acid → HCID 66615856, compound

HRID 76041Notes

Reaction equation

HRID 76041 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[O:24][C:23]([NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=4)=[N:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[Cl:32][C:28]1[CH:27]=[C:26]([NH:25][C:23]2[O:24][C:20]([C:17]3[CH:18]=[CH:19][C:14]([C:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=4)=[CH:15][CH:16]=3)=[CH:21][N:22]=2)[CH:31]=[CH:30][CH:29]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 666158304-{4-[2-(3-Chlorophenylamino)-oxazol-5-yl]-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66615856HCID 66615856, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-{4-[2-(3-chlorophenylamino)-oxazol-5-yl]-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (2.5 g, 5.5 mmol) in MeOH (1 mL) is added 4M HCl in dioxane (3 mL) and the mixture is stirred at RT for 2 h. It is concentrated and used in the next step as the bis HCl salt: (M+H)+352.1.

Workup

  1. concentrationIt is concentrated

Sources & evidence

ORD record
ord-3e55c79cf2f748c7a39ab4b0f54f792a
Source dataset
uspto-grants-2014_09
Patent number
US08835451B2

Reaction notes

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