反应详情

温度

50 °C

A flask was charged with 5-amino-1-methyl-1H-indole (8.8 g; 60 mmol), thiocarbonyl diimidazole (10.7 g; 60 mmol) and ethyl acetate (200 mL). The reaction was heated at 50° C. for five minutes, and after cooling, the solvent was evaporated. The crude material was dissolved in dichloromethane (100 mL) and filtered through a short plug of silica gel, which was washed with another bolus of dichloromethane (100 mL). The organic eluent was evaporated to give 5-isothiocyanato-1-methyl-1H-indole (8.9 g; 47 mmol).

1. temperatureafter cooling
2. customthe solvent was evaporated
3. dissolutionThe crude material was dissolved in dichloromethane (100 mL)
4. filtrationfiltered through a short plug of silica gel, which
5. washwas washed with another bolus of dichloromethane (100 mL)
6. customThe organic eluent was evaporated