1,1'-Carbonyldiimidazole → 2-(6-Chloropyridin-3-YL)acetamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To 10.0 g (58.3 mmol) (2-chloropyridyl)-5-acetic acid in 150 mL THF are added 9.45 g (58.3 mmol) CDI and the mixture is stirred at 45° C. for 1 h. Then 28.0 g (291 mmol) NH4CO3 are added and the mixture is stirred at r.t. over night. The reaction mixture is poured onto water and extracted with EtOAc. The organic layer is dried with MgSO4 and the solvent is removed in vacuo. The residue is triturated with TBME and recrystallized from EtOH.

Herkunft & Nachweise