反应详情

温度

45 °C

To 10.0 g (58.3 mmol) (2-chloropyridyl)-5-acetic acid in 150 mL THF are added 9.45 g (58.3 mmol) CDI and the mixture is stirred at 45° C. for 1 h. Then 28.0 g (291 mmol) NH4CO3 are added and the mixture is stirred at r.t. over night. The reaction mixture is poured onto water and extracted with EtOAc. The organic layer is dried with MgSO4 and the solvent is removed in vacuo. The residue is triturated with TBME and recrystallized from EtOH.

1. stirringthe mixture is stirred at r.t. over night
2. additionThe reaction mixture is poured onto water
3. extractionextracted with EtOAc
4. dry with materialThe organic layer is dried with MgSO4
5. customthe solvent is removed in vacuo
6. customThe residue is triturated with TBME
7. customrecrystallized from EtOH