反应详情

To 2.00 g (11.7 mmol) 2-(6-chloropyridin-3-yl)-acetamide in 50 mL THF at 0° C. are added 12.9 ml LAH (c=1 mol/l in THF) by a dropping funnel. Cooling is removed and the reaction mixture is stirred for 1 h at r.t., then 8 ml LAH (c=1 mol/l in THF) are added and the reaction mixture is stirred at r.t. over night. The reaction is carefully quenched by the addition of 2 ml of an aq. NaHCO3 solution (10%). The mixture is filtrated and the solvent is removed under reduced pressure. The crude product is used without further purification.

1. temperatureCooling
2. customis removed
3. addition8 ml LAH (c=1 mol/l in THF) are added
4. stirringthe reaction mixture is stirred at r.t. over night
5. customThe reaction is carefully quenched by the addition of 2 ml of an aq. NaHCO3 solution (10%)
6. filtrationThe mixture is filtrated
7. customthe solvent is removed under reduced pressure
8. customThe crude product is used without further purification