Hydrochloric Acid → 1-(4-Bromophenyl)-2-methylpropan-2-amine

HRID 76150Notes

Reaction equation

HRID 76150 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:12]C=O)([CH3:11])[CH3:10])=[CH:4][CH:3]=1.Cl>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88861428N-[2-(4-Bromo-phenyl)-1,1-dimethyl-ethyl]-formamide

Product 1

HCID 738391-(4-Bromophenyl)-2-methylpropan-2-amine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

28.0 g (109 mmol) N-[2-(4-bromo-phenyl)-1,1-dimethyl-ethyl]-formamide (I35) are added to 102 mL water and 101 mL (1218 mmol) conc. HCl and stirred at reflux for 8 h. Then heating is stopped and the mixture is stirred at r.t. over night. The precipitate is filtered, washed with TBME and dried in vacuo.

Workup

  1. temperatureat reflux for 8 h
  2. temperatureThen heating
  3. stirringthe mixture is stirred at r.t. over night
  4. filtrationThe precipitate is filtered
  5. washwashed with TBME
  6. customdried in vacuo

Sources & evidence

ORD record
ord-f8a18864ff4746708a87adb81a439350
Source dataset
uspto-grants-2014_09
Patent number
US08835472B2

Reaction notes

Loading…