反应详情

28.0 g (109 mmol) N-[2-(4-bromo-phenyl)-1,1-dimethyl-ethyl]-formamide (I35) are added to 102 mL water and 101 mL (1218 mmol) conc. HCl and stirred at reflux for 8 h. Then heating is stopped and the mixture is stirred at r.t. over night. The precipitate is filtered, washed with TBME and dried in vacuo.

1. temperatureat reflux for 8 h
2. temperatureThen heating
3. stirringthe mixture is stirred at r.t. over night
4. filtrationThe precipitate is filtered
5. washwashed with TBME
6. customdried in vacuo