反应详情

温度

0 °C

A mixture of 12.0 g (43.3 mmol) 2-amino-3-(4-iodophenyl)-propan-1-ol (I41) and 350 mL THF is cooled down to 0° C. 3.81 g (95 mmol) NAH (60% in min. oil) are carefully added and the mixture is stirred at 0° C. for 30 min. 3.25 mL (52.0 mmol) iodomethane are added and cooling is removed. The reaction mixture is stirred at r.t. for 1 h. The mixture is poured onto water and extracted with EtOAc (2×). The combined organic layers are washed with brine, dried with Na2SO4 and the solvent is removed in vacuo. The compound is used without further purification.

1. addition3.81 g (95 mmol) NAH (60% in min. oil) are carefully added
2. temperaturecooling
3. customis removed
4. stirringThe reaction mixture is stirred at r.t. for 1 h
5. additionThe mixture is poured onto water
6. extractionextracted with EtOAc (2×)
7. washThe combined organic layers are washed with brine
8. dry with materialdried with Na2SO4
9. customthe solvent is removed in vacuo
10. customThe compound is used without further purification