反应详情

To 21.0 g (97.6 mmol) 2-(4-bromophenyl)-propan-2-ol in 1 L ACN are added 16.1 mL conc. H2SO4 dropwise while keeping the temperature at 20° C. The resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is partitioned between water and diethylether. The organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×). The solution is dried with MgSO4 and the solvent is removed in vacuo. The crude product is triturated with PE.

1. customat 20° C
2. customThe solvent is removed in vacuo
3. customthe residue is partitioned between water and diethylether
4. washThe organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×)
5. dry with materialThe solution is dried with MgSO4
6. customthe solvent is removed in vacuo
7. customThe crude product is triturated with PE