Sulfuric Acid → N-(2-(4-Bromophenyl)propan-2-YL)acetamide

HRID 76161ノート

反応式

HRID 76161 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](O)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[OH:12]S(O)(=O)=O.[C:17](#[N:19])[CH3:18]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:19][C:17](=[O:12])[CH3:18])([CH3:10])[CH3:9])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 126819202-(4-Bromophenyl)propan-2-ol

生成物 1

HCID 39616691N-(2-(4-Bromophenyl)propan-2-YL)acetamide

実験手順

To 21.0 g (97.6 mmol) 2-(4-bromophenyl)-propan-2-ol in 1 L ACN are added 16.1 mL conc. H2SO4 dropwise while keeping the temperature at 20° C. The resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is partitioned between water and diethylether. The organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×). The solution is dried with MgSO4 and the solvent is removed in vacuo. The crude product is triturated with PE.

後処理

  1. customat 20° C
  2. customThe solvent is removed in vacuo
  3. customthe residue is partitioned between water and diethylether
  4. washThe organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×)
  5. dry with materialThe solution is dried with MgSO4
  6. customthe solvent is removed in vacuo
  7. customThe crude product is triturated with PE

出典と根拠

ORDレコード
ord-a749d125b04e4af1b21bf3151fe5dd09
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

反応ノート

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