Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 57934248 | HCID 57934248 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Iodophentermine | HCID 126028 | — |
Reaction Steps
To 1.10 g (2.93 mmol) [2-(4-iodophenyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester (I52.9) in 8 ml methanol are added 7.04 ml HCl (1.25 mol/l in MeOH) and the solution is stirred at 50° C. for 3 h. The solvent is removed under reduced pressure and the resulting crude product is purified by HPLC (H2O/MeOH/NH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08835472B2 |
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| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-97eac24a6fdf41119e6ae7263419f573 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
