Hydrochloric Acid → 4-Iodophentermine

HRID 76164Notes

Reaction equation

HRID 76164 reaction equation
C(OC(=O)[NH:7][C:8]([CH3:18])([CH3:17])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=1)(C)(C)C.Cl>CO>[I:16][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][C:8]([NH2:7])([CH3:17])[CH3:18])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57934248HCID 57934248, compound

Product 1

HCID 1260284-Iodophentermine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To 1.10 g (2.93 mmol) [2-(4-iodophenyl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester (I52.9) in 8 ml methanol are added 7.04 ml HCl (1.25 mol/l in MeOH) and the solution is stirred at 50° C. for 3 h. The solvent is removed under reduced pressure and the resulting crude product is purified by HPLC (H2O/MeOH/NH3).

Workup

  1. customThe solvent is removed under reduced pressure
  2. customthe resulting crude product is purified by HPLC (H2O/MeOH/NH3)

Sources & evidence

ORD record
ord-97eac24a6fdf41119e6ae7263419f573
Source dataset
uspto-grants-2014_09
Patent number
US08835472B2

Reaction notes

Loading…