反应详情

温度

50 °C

To a solution of [6-methoxycarbonyl-2-(4-propionylamino-phenyl-sulfanyl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine (2 g, 4.85 mmol) in THF (100 mL) is added lithium borohydride (0.32 g, 14.5 mmol). The reaction mixture is stirred at 50° C. for 1.5 hours. The reaction is then quenched with dilute HCl and extracted with ethyl acetate. The organic layer is successively washed with aqueous saturated NaHCO3 and brine, dried over MgSO4 and evaporated. The solid residue is triturated in ethyl acetate and the resulting white solid is collected by filtration to give the desired product [6-hydroxymethyl-2-(4-propionylamino-phenyl-sulfanyl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine.

1. customThe reaction is then quenched with dilute HCl
2. extractionextracted with ethyl acetate
3. washThe organic layer is successively washed with aqueous saturated NaHCO3 and brine
4. dry with materialdried over MgSO4
5. customevaporated
6. customThe solid residue is triturated in ethyl acetate
7. filtrationthe resulting white solid is collected by filtration