Hydrochloric Acid → 2-[4-(4-Propoxy-phenylethynyl)-phenyl]-propylamine

Participants

Reaction Steps

To 0.70 g (1.78 mmol) tert-butyl 2-(4-((4-propoxyphenyl)ethynyl)phenyl)propyl-carbamate (I61.1) in 5 mL MeOH are added 4.27 mL (5.34 mmol) HCl (1.25M in MeOH). The mixture is stirred at r.t. over night. The solvent is removed in vacuo and the crude product is treated with aq. NaHCO3 solution. The precipitate is filtered, washed with water and dried at 50° C. in vacuo.

Provenance & Evidence