反应详情

To 0.70 g (1.78 mmol) tert-butyl 2-(4-((4-propoxyphenyl)ethynyl)phenyl)propyl-carbamate (I61.1) in 5 mL MeOH are added 4.27 mL (5.34 mmol) HCl (1.25M in MeOH). The mixture is stirred at r.t. over night. The solvent is removed in vacuo and the crude product is treated with aq. NaHCO3 solution. The precipitate is filtered, washed with water and dried at 50° C. in vacuo.

1. customThe solvent is removed in vacuo
2. additionthe crude product is treated with aq. NaHCO3 solution
3. filtrationThe precipitate is filtered
4. washwashed with water
5. customdried at 50° C. in vacuo