Hydrochloric Acid → 4-Iodophentermine

HRID 76174Notes

Reaction equation

HRID 76174 reaction equation
C(OC(=O)[NH:7][C:8]([CH3:18])([CH3:17])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=1)(C)(C)C.Cl>CO>[I:16][C:13]1[CH:12]=[CH:11][C:10]([CH2:9][C:8]([NH2:7])([CH3:17])[CH3:18])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57934248HCID 57934248, compound

Product 1

HCID 1260284-Iodophentermine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To 1.10 g (2.93 mmol) 2-(4-iodophenyl)-1,1-dimethyl-ethyl-carbamic acid tert-butyl ester (I52.9) in 10 mL MeOH are added 7.04 mL (8.80 mmol) HCl (1.25M in MeOH). The mixture is stirred at 50° C. for 3 h. The solvent is removed in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by HPLC (MeOH/H2O/NH3)

Sources & evidence

ORD record
ord-17b0fcb4e00947478246cbefdffe39a0
Source dataset
uspto-grants-2014_09
Patent number
US08835472B2

Reaction notes

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