反应详情

To a mixture of 6.00 g (17.9 mmol) methyl 3-((4-(2-acetamido-propyl)phenyl)ethynyl)-benzoate (I71.1) in 150 mL MeOH are added at 0° C. 18 mL LiOH solution (3 M in water). The reaction mixture is stirred at r.t. over night. The MeOH is removed in vacuo and the desired product is precipitated by acidification with 2N aq. HCl. The resulting solid is filtered, washed with pentane and dried in vacuo.

1. additionare added at 0° C
2. customThe MeOH is removed in vacuo
3. customthe desired product is precipitated by acidification with 2N aq. HCl
4. filtrationThe resulting solid is filtered
5. washwashed with pentane
6. customdried in vacuo