HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76191Generated: October 28, 2026
Ethanol → N-(1-(4-((2-ethoxypyrimidin-4-yl)ethynyl)phenyl)propan-2-yl)acetamide
https://huagongshe.com/reaction/76191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 86669623 | HCID 86669623 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(1-(4-((2-ethoxypyrimidin-4-yl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 66611197 | — |
Reaction Steps
25 mg (0.08 mmol) N-(1-(4-((2-chloropyrimidin-4-yl)ethynyl)phenyl)propan-2-yl)acetamide (170) in 1.0 mL dioxane are added to 9.3 μl (0.16 mmol) ethanol in 0.5 ml dioxane and cooled down to 0° C. 10 mg (0.24 mmol) NaH are added and the mixture is stirred at r.t. over night. The reaction is quenched with water and the solvent is evaporated in vacuo. The residue is purified by HPLC (MeOH/H2O/TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08835472B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-c99b70657a8b41d5b8cecebbb3ecf696 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
