反应详情

温度

0 °C

25 mg (0.08 mmol) N-(1-(4-((2-chloropyrimidin-4-yl)ethynyl)phenyl)propan-2-yl)acetamide (170) in 1.0 mL dioxane are added to 9.3 μl (0.16 mmol) ethanol in 0.5 ml dioxane and cooled down to 0° C. 10 mg (0.24 mmol) NaH are added and the mixture is stirred at r.t. over night. The reaction is quenched with water and the solvent is evaporated in vacuo. The residue is purified by HPLC (MeOH/H2O/TFA).

1. customThe reaction is quenched with water
2. customthe solvent is evaporated in vacuo
3. customThe residue is purified by HPLC (MeOH/H2O/TFA)