HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(1-(4-((2-((2-Methoxyethyl)(methyl)amino)pyrimidin-5-yl)ethynyl)phenyl)propan-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| Reactant | N-(1-(4-((2-Chloropyrimidin-5-yl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 86669620 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(1-(4-((2-((2-Methoxyethyl)(methyl)amino)pyrimidin-5-yl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 66614556 | — |
Reaction Steps
28.2 mg (0.09 mmol) N-(1-(4-((2-chloropyrimidin-5-yl)ethynyl)phenyl)propan-2-yl)-acetamide (I69.1) in 1.5 mL DMSO are added to 12.0 mg (0.14 mmol) N-(2-methoxyethyl)-methylamine followed by 21.8 μl (0.14 mmol) DIPEA. The reaction mixture is stirred at r.t. over night and is directly purified by HPLC (MeOH/H2O/TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835472B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-730f548fa70541aebc007762dab2597c |
| Source note | uspto-grants-2014_09 |