huagongshe.com
HRID76192

反应详情

EQUATION

反应方程式

HRID 76192 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CNCCOC
HCID300977

N-(2-Methoxyethyl)methylamine

C4H11NO

结构：CC(=O)NC(C)Cc1ccc(C#Cc2cnc(Cl)nc2)cc1
HCID86669620

未命名化合物

PRODUCTS

生成物

1
结构：COCCN(C)c1ncc(C#Cc2ccc(CC(C)NC(C)=O)cc2)cn1
HCID66614556

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

28.2 mg (0.09 mmol) N-(1-(4-((2-chloropyrimidin-5-yl)ethynyl)phenyl)propan-2-yl)-acetamide (I69.1) in 1.5 mL DMSO are added to 12.0 mg (0.14 mmol) N-(2-methoxyethyl)-methylamine followed by 21.8 μl (0.14 mmol) DIPEA. The reaction mixture is stirred at r.t. over night and is directly purified by HPLC (MeOH/H2O/TFA).

WORKUP

后处理

  1. customis directly purified by HPLC (MeOH/H2O/TFA)