HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76206Generated: October 29, 2026
Methyl chloroformate → HCID 66611160, compound
https://huagongshe.com/reaction/76206
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)ethanamine | HCID 66610326 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 66611160 | HCID 66611160 | — |
Reaction Steps
To 26.5 mg (0.10 mmol) 1-[4-(4-ethoxy-phenylethynyl)-phenyl]-ethylamine (I63) in 2.00 mL acetone are added 47.7 mg (0.45 mmol) Na2CO3 and 10.2 μL methyl chloroformate. The reaction mixture is stirred at 40° C. for 3 h. After cooling down to r.t. the reaction mixture is filtered and the solvent is removed in vacuo. The residue is purified by HPLC (MeOH/H2O/TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08835472B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-87bf132310614ab08924459b9b605cf9 |
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| Source note | uspto-grants-2014_09 |
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