Hexanal → HCID 86626354, compound

HRID 76305Notes

Reaction equation

HRID 76305 reaction equation
Cl.[F:2][CH2:3][C:4]([CH3:7])([NH2:6])[CH3:5].S([O-])([O-])(=O)=O.[Mg+2].C(=O)([O-])[O-].[K+].[K+].[CH:20](=O)[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>ClCCl>[F:2][CH2:3][C:4]([CH3:7])([N:6]=[CH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH3:5]

Participants

6

Reactant 4

HCID 6184HexanalHCID 11430Potassium CarbonateHCID 24083Sulfuric acid magnesium salt (1:1)HCID 139352511-Fluoro-2-methylpropan-2-amine hydrochloride

Product 1

HCID 86626354HCID 86626354, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 1-fluoro-2-methylpropan-2-amine hydrochloride (ABCR) (2 g, 15.7 mmol), anhydrous magnesium sulfate (3.77 g, 31.4 mmol) and potassium carbonate (2.17 g, 15.68 mmol) in dichloromethane (100 mL) was added drop wise hexanal (1.93 mL, 15.7 mmol) at 0° C. The reaction mixture was stirred for 10 h at room temperature, then filtered and concentrated to obtain the title compound as a pale yellow liquid.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-c829ad5c8c004e5c85e2ea643e0ba45b
Source dataset
uspto-grants-2014_09
Patent number
US08835475B2

Reaction notes

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