Hydrochloric Acid → 2-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride

HRID 76348Notes

Reaction equation

HRID 76348 reaction equation
C(OC([N:8]1[CH2:13][CH:12]([CH3:14])[N:11]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(O)C>[ClH:22].[CH3:21][CH:10]1[CH2:9][NH:8][CH2:13][CH:12]([CH3:14])[N:11]1[C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 594069863,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 684321412-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester (294 mg) was dissolved in ethanol (2 ml), 4N hydrochloric acid (ethyl acetate solution, 2 ml) was added and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated, and ethyl acetate (3 ml) was added to the obtained residue. The solid insoluble in ethyl acetate was collected by filtration and dried to give the title compound (281 mg).

Workup

  1. customThe solvent was evaporated
  2. additionethyl acetate (3 ml) was added to the obtained residue
  3. filtrationThe solid insoluble in ethyl acetate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-0f6935ec524f430c8a1dde00e0ae3fff
Source dataset
uspto-grants-2014_09
Patent number
US08835631B2

Reaction notes

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