Benzoic Acid → HCID 89846704, compound

Participants

Reaction Steps

To 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine (15.52 g, 63.3 mmol) was added toluene (75 mL). Benzoic acid (7.73 g, 63.3 mmol) was added in one portion. The reaction mixture was stirred for 18 hours and the white precipitate that formed was filtered and washed with toluene (3×30 mL) to give 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine benzoic acid salt (16.15 g, 44.0 mmol, 69%) as a white solid containing 10% toluene by weight.

Provenance & Evidence