反应详情

To 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine (15.52 g, 63.3 mmol) was added toluene (75 mL). Benzoic acid (7.73 g, 63.3 mmol) was added in one portion. The reaction mixture was stirred for 18 hours and the white precipitate that formed was filtered and washed with toluene (3×30 mL) to give 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine benzoic acid salt (16.15 g, 44.0 mmol, 69%) as a white solid containing 10% toluene by weight.

1. customthe white precipitate that formed
2. filtrationwas filtered
3. washwashed with toluene (3×30 mL)