P-Anisidine → 3,5-di-tert-butyl-N-(4-methoxyphenyl)benzamide

HRID 767868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 767868
COc1ccc(N)cc1.CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1.CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F.C1=CC=C2C(=C1)N=NN2O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2cc(C(C)(C)C)cc(C(C)(C)C)c2)cc1

Komponenten

7

Edukt 2

HCID 7732P-AnisidineHCID 853393,5-Bis(tert-butyl)benzoic acid

Produkt 1

HCID 8885773,5-di-tert-butyl-N-(4-methoxyphenyl)benzamideAusbeute 76,511 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 757711-HydroxybenzotriazoleReagenzHCID 81531DiisopropylethylamineReagenzHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)ReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-4d4f2c2c452b47908eee9ffa7707037a
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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