2-Pyrrolidone → 1-(3-(Benzylthio)-2-methylphenyl)pyrrolidin-2-one

HRID 76811Notes

Reaction equation

HRID 76811 reaction equation
[CH2:1]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11](Br)[C:10]=1[CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:21][CH2:20][CH2:19][C:18]1=[O:22]>>[CH2:1]([S:8][C:9]1[C:10]([CH3:16])=[C:11]([N:17]2[CH2:21][CH2:20][CH2:19][C:18]2=[O:22])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 66911186Benzyl(3-bromo-2-methylphenyl)sulfane

Product 1

HCID 669111271-(3-(Benzylthio)-2-methylphenyl)pyrrolidin-2-one

Procedure

Intermediate 24 (14.08 g, 48 mmol) and pyrrolidin-2-one (4.9 g, 57.6 mmol) were converted to intermediate 25 as described in example 1; 1.5). The crude product (14.6 g) was used without purification in the next step.

Workup

  1. customThe crude product (14.6 g) was used without purification in the next step

Sources & evidence

ORD record
ord-e50f37a17a0c431eb0ab23a5be0457ad
Source dataset
uspto-grants-2014_09
Patent number
US08835653B2

Reaction notes

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