反应详情

温度

100 °C

50 ml of concentrated sulphuric acid was added to 1-chloroethynyl-2,4,5-trifluorobenzene of formula IV, X═Cl and the mixture heated to 100° C. and left to stir for 1 hour. 50 ml of MTBE and 100 ml of water were then added. The phases were separated and the aqueous phase was re-extracted with 2×50 ml of MTBE. The combined organic phases were counter extracted with 3×50 ml of aqueous NaHCO3 and put to one side. The three aqueous phases of NaHCO3 were recombined and the resulting phase was acidified with hydrochloric acid and then extracted with 3×50 ml of MTBE. The organic phases were concentrated to a residue obtaining 0.25 g of 2,4,5-trifluorophenylacetic acid of formula (I) with a molar yield of 25%.

1. waitleft
2. customThe phases were separated
3. extractionthe aqueous phase was re-extracted with 2×50 ml of MTBE
4. extractionThe combined organic phases were counter extracted with 3×50 ml of aqueous NaHCO3
5. extractionextracted with 3×50 ml of MTBE
6. concentrationThe organic phases were concentrated to a residue