反应详情

A solution of the title compound of step 2 (1.38 g, 5.53 mmol) and hydroxylamine hydrochloride (576 mg, 8.3 mmol) in abs. ethanol (20 mL) were mixed with Amberlyst A 21 (3.9 g) and stirred for 16 h at RT. The ion exchanger was filtered off, the solution concentrated to low volume and the residue made alkaline with 1N NaOH. The aqueous phase was extracted with ethyl acetate, dried over Na2SO4 and concentrated to low volume in a vacuum.

1. filtrationThe ion exchanger was filtered off
2. concentrationthe solution concentrated to low volume
3. extractionThe aqueous phase was extracted with ethyl acetate
4. dry with materialdried over Na2SO4
5. concentrationconcentrated to low volume in a vacuum