反应详情

The title compound from step 1 (200 mg, 0.528 mmol) was dissolved in abs. THF (15 mL). LiAlH4 (39 mg, 1.06 mmol) was added in argon. The batch was boiled for 7 h with reflux. The batch was then cooled to room temperature, mixed with THF (12 mL) and H2O (5 mL) with ice cooling and subsequently stirred for 30 min. The batch was filtered over a fritted glass filter with diatomaceous earth and subsequently rinsed with dichloromethane (50 mL). The combined filtrates were concentrated to low volume in a vacuum.

1. temperaturewith reflux
2. filtrationThe batch was filtered over a fritted glass
3. filtrationfilter with diatomaceous earth
4. washsubsequently rinsed with dichloromethane (50 mL)
5. concentrationThe combined filtrates were concentrated to low volume in a vacuum