Methoxymethyl-triphenylphosphonium chloride → 4-Dimethylamino-4-phenylcyclohexanecarbaldehyde

Tert-BuOK (8.41 g, 75 mmol) dissolved in abs. THF (100 mL) was added in drops to a solution of (methoxymethyl)triphenyl phosphonium chloride (25.7 g, 75.0 mmol) in abs. THF (100 mL) at 0° C. in argon. The resulting red solution was mixed after 30 min at 0° C. with a solution of 4-dimethylamino-4-phenyl cyclohexanone (10.9 g, 50.0 mmol) in abs. THF (100 mL) and stirred overnight at RT. The solvent was removed in a vacuum, the residue mixed with 1N sulphuric acid (150 mL) and stirred for 2 h. The precipitate precipitated out during this was separated and the filtrate (pH 1) washed with ether (6×100 mL). The aqueous solution was adjusted to pH 11 with 5N NaOH and extracted with ethyl acetate (3×100 mL). The combined organic phases were dried over Na2SO4 and concentrated to low volume in a vacuum.

1. customat 0° C.
2. customThe solvent was removed in a vacuum
3. additionthe residue mixed with 1N sulphuric acid (150 mL)
4. customThe precipitate precipitated out during
5. customthis was separated
6. washthe filtrate (pH 1) washed with ether (6×100 mL)
7. extractionextracted with ethyl acetate (3×100 mL)
8. dry with materialThe combined organic phases were dried over Na2SO4
9. concentrationconcentrated to low volume in a vacuum

ORD record

ord-016ffc60082d4f1a8dd57ecd469dfbdc

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08835689B2